This research reports an asymmetric Mannich reaction to synthesize C2-quaternary indolin-3-ones, indicating unprecedented diastereoselectivity and stereoselectivity.
Described here is a chiral phosphoric acid (CPA)-catalyzed asymmetric Mannich reaction of 3,3-difluoro-2-aryl-3H-indoles with cycloketones to produce C2-quaternary indolin-3-ones. Notable features of this method include: (1) unprecedented diastereoselectivity and high stereoselectivity; (2) access to not-fully-explored diastereomers.
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Zhang et al. (2025) studied this question.
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