Anti‐influenza Virus Heptaketides From a Marine‐associated Fungus Aspergillus sp.

Four new heptaketides ( 1–4 ), along with 11 known compounds ( 5–15 ), were isolated from the marine‐associated fungus Aspergillus sp. JGT‐1‐3‐1. The structures of the new compounds were elucidated through comprehensive analysis of nuclear magnetic resonance (one‐ and two‐dimensional) and high‐resolution electrospray ionization mass spectrometry spectroscopic data, and their absolute configurations were determined by comparing theoretical and experimental electronic circular dichroism spectra. Notably, all newly identified heptaketides exhibited significant anti‐influenza A virus activity, with half‐maximal inhibitory concentration values below 2 µg/mL, as assessed by the cytopathic effect assay.