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September 12, 2025

Physiological changes and some blood biomarkers in Iraqi women with polycystic ovary syndrome

Key Points

PCOS patients showed increased Follistatin and Vaspin levels compared to controls, and reduced Ghrelin levels.
Follistatin and Vaspin positively correlated with BMI, indicating their potential as biomarkers for PCOS.
The study analyzed 85 PCOS patients and 50 healthy controls to assess these hormonal changes.
Findings suggest a robust connection between hormonal disorders and BMI in women with PCOS.

Abstract

Although the pathophysiology of PCOS is still unknown, but the alterations in some endocrinological systems have been appear to link with it. The aim of this study is to assess the effect of some endocrinological parameters ( Follistatin , Vaspin and Ghrelin ) in PCOS patients in compared with healthy control as well as it correlate with BMI ( body mass index ) as a novel biomarkers for PCOS pathophysiology .This study was conducted on 85 PCOS patients ( age range 18 – 45 years) who were attended Al-Ramadi of obstetrician – gynecologist hospital and Fallujah in of obstetrician – gynecologist hospital the period 7 January to 4 May 2025 and 50 healthy control were recruited for this study.The obtained results was showed the increase of the of Follisatin and Vaspin levels in PCOS patients in compare with control group, with evident decrease observed in levels of ghrelin in PCOS patients as compared with control group. This study also found that Follisatin and Vaspin were positively correlated with BMI while Ghrelin were negative correlated with BMI in PCOS patients as compared to control group.It was concluded that there was a robust association between Follisatin, Vaspin and Ghrelin disorders with BMI index in women with PCOS.

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