This case reports a woman with amyopathic dermatomyositis and triple-negative breast cancer, indicating the need for oncologic screening.
Amyopathic dermatomyositis (ADM) is a rare form of dermatomyositis characterized by specific cutaneous lesions without muscle involvement. It can reveal an underlying malignancy, particularly breast carcinoma. We report the case of a 48-year-old woman presenting with a skin eruption suggestive of ADM, preceding the diagnosis of triple-negative breast cancer. Paraneoplastic etiology was confirmed by the presence of anti-TIF1γ antibodies. Management included corticosteroids, intravenous immunoglobulins, and neoadjuvant chemotherapy followed by mastectomy, resulting in rapid improvement in cutaneous manifestations. One-year post-treatment, no recurrence has been observed. This case highlights the importance of systematic oncologic screening in ADM and the value of multidisciplinary care.
No takes yet. Share an insight, caveat, or question.
Chaouni et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: