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September 12, 2025International Journal of BioprintingOpen Access

3D-printed collagen scaffold and adipose tissue mesenchymal stem cells-derived limbal stem cells for the treatment of limbal stem cell deficiency

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Authors

MSMartha StokkingMCMarta Cadenas-MartínAMAna Martín-González

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Overview

This research demonstrates improved outcomes for limbal stem cell deficiency using 3D-printed collagen scaffolds and adipose-derived stem cells, indicating effective healing potential.

Key Points

  • 3D-printed collagen scaffolds integrated more effectively than amniotic membrane for treating LSCD.
  • In vitro differentiation showed 3D-printed collagen yielding higher LSC markers compared to standard methods.
  • Adipose-derived stem cells successfully transformed into limbal stem cells, enhancing treatment efficacy.
  • The generated epithelium from ADSC-derived LSCs was primarily conjunctival, indicating incomplete corneal re-epithelization.

Cite This Study

Stokking et al. (2025) studied this question.

synapsesocial.com/papers/68d44b3f31b076d99fa550dfhttps://doi.org/10.36922/ijb025290293
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