Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease

Abstract Accurate use of subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 36 patients, we validated three estimation methods for pseudo-monopolar beta power. A Euclidean distance-based approach performed best. Maximal beta power was stable across 20-second windows in ≥ 80% of ring but only ≥ 60% of directional channels. In 69% of hemispheres contacts with highest estimated beta power were clinically active one year after surgery.