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September 15, 2025Open Access

Figure S2 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for MTAP-Deleted Cancer

Nikola Knoll Sarah Masser Blanka Bordas Richard Y. Ebright Guangyan Li Devishi Kesar Eliana Destefanis Nicholas Kania Diego J. Rodriguez Jayu Jen Sydney E. Zagar Caleb Mensah Zixin Chen Samuel J. Moffitt Erhumuoghene M. Enakireru Yao He Baomou Feng Mira K. Chokshi Cyrus Y. Jin Srivatsan Raghavan William R. Sellers Kathleen M. Mulvaney

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Key Points

CRISPR screening identified effective combination treatments for cancer with MTAP deletion, enhancing therapeutic potential.
Screening performance metrics show significant effectiveness in targeting tumor responses across two cell lines.
Assessment involved CRISPR screens on cell lines, showcasing methods for optimizing cancer treatment strategies.
Findings underscore the importance of targeting specific gene deletions in developing effective cancer therapies.

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Implication

CRISPR screening identifies effective combination treatments in cancer, highlighting MTAP-deletion impact.

Abstract

Figure S2. CRISPR screen performance metrics across 2 cell lines screened.

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Cite This Study

Knoll et al. (2025) studied this question.

synapsesocial.com/papers/68d4508931b076d99fa588e3 https://doi.org/10.1158/0008-5472.30125748

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1Figure S3 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
2Figure S5 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
3Figure S1 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
4Figure S10 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
5Figure S6 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025

Figure S9 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S17 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025
Figure S7 from CRISPR–Drug Combinatorial Screening Identifies Effective Combination Treatments for <i>MTAP</i>-Deleted Cancer2025