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September 15, 2025

Supplementary Figure S4 from UBE2T-Mediated HP1α Ubiquitination Enhances Nucleolar Function and Promotes the Progression of IDH1/TP53-Mutant Glioma

Fengqi Zhou Yuanyuan Sun Xinhua Chen Di Wu Zhennan Tao Lingyun Wu Gao Chen Xiangyu Liu Tianfu Yu

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Key Points

UBE2T-mediated ubiquitination enhances nucleolar function, suggesting a crucial role in glioma progression.
iTRAQ and RNA-seq analyses reveal significant changes in gene expression linked to UBE2T and nucleolar activities.
Observational analysis focusing on IDH1/TP53-mutant glioma shows how molecular mechanisms drive tumor development.
These findings highlight UBE2T's potential as a therapeutic target in glioma treatments.

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Implication

Analysis shows how UBE2T-mediated ubiquitination impacts nucleolar function in glioma, indicating its role in tumor progression.

Abstract

Supplementary Figure S4: iTRAQ and RNA-seq analysis.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/68d4538731b076d99fa58964 https://doi.org/10.1158/1078-0432.30125685

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