Multilayer 3D Polymer Probe for Selective Cr 6+ Monitoring and Stereochemical Recognition

Two benzofuran derivatives with distinct substituents at the 4- and 6-positions were employed to successfully synthesize a multilayered chiral three-dimensional polymer exhibiting aggregation-induced emission (AIE) activity via Suzuki cross-coupling reactions. This approach effectively integrates molecular design with functional sensing capabilities. The resulting polymer possesses a well-defined framework and demonstrates remarkable AIE characteristics along with fluorescence quenching under specific conditions. Notably, it enables ultrasensitive detection of trace Cr 6+ in solution while maintaining exceptional selectivity even in the presence of competing metal ions. Owing to its unique three-dimensional architecture, the polymer displays outstanding ion selectivity and stereochemical recognition, with robust performance resistant to environmental interference. Experimental data confirm a pronounced fluorescence intensity change upon interaction with hexavalent chromium ions (Cr 6+ ), underscoring its potential as a highly promising fluorescent probe for environmental pollutant monitoring. This dual-functional platform, which combines environmental sensing with biomedical chiral recognition, not only bridges the gap between molecular engineering and practical detection applications but also provides innovative research perspectives and technical avenues for developing stable fluorescent sensors targeting heavy metal ions.