PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
Synapse
⌘+K
Synapse
September 16, 2025Open Access

An Aurora Kinase A/TPX2 complex phosphorylates CKAP2 to control mitotic spindle growth

View Full Paper
Ask AI
Bookmark
Share

Authors

TKThomas J. KucharskiTLTatiana LyalinaSBSusanne Bechstedt

Discussion

Loading...

Member takes

Overview

Study reveals how phosphorylation by aurora kinase a influences mitotic spindle growth in cells, suggesting a key role for ckap2.

Key Points

  • Aurora kinase a phosphorylates ckap2, reducing its affinity for microtubules and impacting spindle dynamics.
  • Analysis of proteins interacting with ckap2 identified aurora kinase a and tpx2, linked to mitotic stability.
  • CKAP2 phosphorylation leads to smaller mitotic spindles in cells, indicating its critical role in chromosome segregation.
  • The findings suggest potential pathways for addressing chromosomal instability associated with ckap2 loss.

Cite This Study

Kucharski et al. (2025) studied this question.

synapsesocial.com/papers/68d4539531b076d99fa5930chttps://doi.org/10.1101/2025.09.09.675182
View Full Paper
Ask AI
Bookmark
Share