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Synapse
September 16, 2025Medicine2 citationsOpen Access

Toxic encephalopathy due to mercury: A rare case report and literature review

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MZMaowang ZouJLJunfeng LiHYHongchao Yao

Key Points

  • The case reveals critical MRI findings in toxic encephalopathy from mercury exposure, highlighting its rarity.
  • MRI showed symmetrical alterations, including brain parenchyma changes, marking the severity of mercury poisoning.
  • The patient received sodium dimercaptopropane sulfonate as treatment, but unfortunately, life-saving measures were unsuccessful.
  • Lack of established diagnostic criteria for mercury poisoning emphasizes the need for awareness among clinicians.

Abstract

Mercury toxic encephalopathy is uncommonly encountered in clinical practice. The aim of presenting this case is to increase the awareness of this disease, especially regarding its radiological presentation. Toxic encephalopathy due to mercury. The medical team administered sodium dimercaptopropane sulfonate as a mercury antagonist and treated with plasma purification and massive hydration to promote mercury excretion. Following admission, the patient underwent an magnetic resonance imaging (MRI) examination. The results revealed symmetrical alterations in the brain parenchyma (including both cerebrum and cerebellum), characterized by hypoperfusion on MRI perfusion imaging. The patient died after a series of lifesaving measures. Mercury poisoning encephalopathy is a rare disorder for which currently established diagnostic criteria are lacking. On brain MRI scans, it manifests as symmetric cerebral edema, involving the parenchyma of both the cerebrum and cerebellum. It is important to question patients carefully about any history of exposure to mercury-containing drugs.

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Cite This Study

Zou et al. (2025) studied this question.

synapsesocial.com/papers/68d4539531b076d99fa59373https://doi.org/10.1097/md.0000000000044037
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