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September 16, 2025Egyptian Pediatric Association GazetteOpen Access

The effectiveness of high-dose versus low-dose corticosteroid therapy in children with acute respiratory distress syndrome: a randomized controlled study

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Early corticosteroid initiation significantly improves outcomes, with 100% survival compared to late initiation, which resulted in 100% mortality.
Clinical outcomes showed no significant differences between high-dose and low-dose methylprednisolone, but early initiation was crucial.
The study included 40 children diagnosed with ARDS, randomized to receive either high or low doses of methylprednisolone.
Both treatment regimens showed similar effects on clinical, biomarker, and radiological outcomes, emphasizing the importance of timing.

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Implication

Randomized controlled trial comparing corticosteroid doses in children with acute respiratory distress syndrome, indicating early initiation improves outcomes.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68d4539c31b076d99fa59606 https://doi.org/10.1186/s43054-025-00429-9

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Implication

Randomized controlled trial comparing corticosteroid doses in children with acute respiratory distress syndrome, indicating early initiation improves outcomes.

The effectiveness of high-dose versus low-dose corticosteroid therapy in children with acute respiratory distress syndrome: a randomized controlled study

Key Points

Discussion

Implication

Cite This Study

The effectiveness of high-dose versus low-dose corticosteroid therapy in children with acute respiratory distress syndrome: a randomized controlled study

Key Points

Discussion

Implication

Cite This Study

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