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September 16, 2025European PsychiatryOpen Access

Mental health approach to premenstrual dysphoric syndrome: case series

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Authors

ÁPÁ. Izquierdo De La PuentePCP. Del Sol CalderónRFRafael Fernández

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Overview

Case series shows improvement with SSRIs for premenstrual dysphoric syndrome, suggesting a non-hormonal approach.

Key Points

  • Treatment with SSRIs reduced symptoms of premenstrual dysphoric syndrome, improving overall mood stability.
  • Patients reported a reduction in MADRS scores from 15.6 on the 14th day to 9.2 on the 5th day of the cycle.
  • The approach involved administering fluoxetine only from ovulation to menstruation, minimizing exposure to side effects.
  • Preliminary results support SSRIs as a safer treatment option, avoiding the side effects associated with hormonal therapies.

Cite This Study

Puente et al. (2025) studied this question.

synapsesocial.com/papers/68d454cb31b076d99fa5a4d1https://doi.org/10.1192/j.eurpsy.2025.2413
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