This research demonstrates regioisomeric product formation in cyclic sulfonamide synthesis, suggesting new pathways for functional group incorporation.
The synthesis of a new class of cyclic sulfonamides (sultams) and their subsequent conversion into substituted N‐heterocycles is reported. Methyl‐substituted tetrahydropyridine and tetrahydro‐azepine Heck precursors are prepared and cyclized to provide a variety of regioisomeric products. Thereafter, the cyclic sulfonamide products are subjected to sulfonyl cleavage to provide several novel phenyl‐substituted N‐heterocycles, each containing functional groups useful for further functionalization.
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STANLEY et al. (2025) studied this question.
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