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September 16, 2025OBM GeriatricsOpen Access

The Role of Telomeres in Senescence, Aging and Disease: Fiction and Reality

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Authors

GSGabriele Saretzki

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Overview

Review highlights the relationship between telomeres, oxidative stress, and aging-related diseases.

Key Points

  • Telomere shortening contributes to replicative senescence and aging by increasing the number of senescent cells in tissues.
  • Many studies suggest a direct link between telomeres and various diseases, emphasizing the genetic influence on telomere length.
  • Removal of senescent cells using senolytic agents can partially reverse the aging effects associated with telomere dysfunction.
  • Oxidative stress, inflammation, and lifestyle choices can significantly impact telomere length and aging dynamics.

Cite This Study

Gabriele Saretzki (2025) studied this question.

synapsesocial.com/papers/68d4565b31b076d99fa5b2aahttps://doi.org/10.21926/obm.geriatr.2503324
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