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September 16, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Impact of antibiotic choice on immune response and antibiotic resistance development in piglets experimentally infected with Escherichia coli

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Authors

LCLeon CantasCFChristopher G. FentonEBEmese Bató

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Overview

Observational analysis showed antibiotic choice affects immune responses and resistance in piglets, indicating critical selection for effective treatment.

Key Points

  • Significantly reduced R-plasmid transfer genes were observed in piglets treated with effective enrofloxacin.
  • Groups receiving ineffective tetracycline showed increased expression of bacterial SOS response genes.
  • The choice of antibiotic directly influences piglet immune responses and the development of antibiotic resistance.
  • Improper use of antibiotics can result in increased morbidity and accelerate the spread of resistance genes.

Cite This Study

Cantas et al. (2025) studied this question.

synapsesocial.com/papers/68d4565b31b076d99fa5b394https://doi.org/10.3389/fcimb.2025.1627782
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