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September 16, 2025Oncology and Translational Medicine2 citationsOpen Access

Controversy and progress in surgical treatment of hilar cholangiocarcinoma

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JCJiye ChenSCShouwang Cai

Key Points

  • Surgical resection is crucial for treating hilar cholangiocarcinoma, yet postoperative prognosis remains suboptimal, indicating a need for improved methods.
  • Advancements like biliary drainage and innovative resection approaches have shown potential to improve outcomes in this challenging malignancy.
  • Reviewing current literature sheds light on the implications of new surgical techniques and reveals ongoing challenges in effective treatment strategies.
  • Future research is essential to tackle unresolved issues and further enhance surgical management of hilar cholangiocarcinoma.

Abstract

Abstract Hilar cholangiocarcinoma, a common biliary tract malignancy, relies on surgical resection as the most effective treatment, yet postoperative prognosis remains suboptimal. Recent advancements in surgical management include preoperative biliary drainage, selection of hepatic resection approaches, innovations in bilioenteric anastomosis techniques, and the application of perioperative chemotherapy. This review synthesizes current literature on these developments, highlighting their clinical implications and unresolved challenges, and prospected the future research direction.

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Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68d4566c31b076d99fa5b9achttps://doi.org/10.1097/ot9.0000000000000112
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma2024 · 35 citations
  2. 2Evolution of Surgical Treatment for Perihilar Cholangiocarcinoma2012 · 662 citations
  3. 3Extent of liver resection for hilar cholangiocarcinoma2009 · 88 citations
  4. 4Gemcitabine, Cisplatin, and nab-Paclitaxel for the Treatment of Advanced Biliary Tract Cancers2019 · 481 citations
  5. 5Randomized Phase III study of gemcitabine plus S-1 versus gemcitabine plus cisplatin in advanced biliary tract cancer: Japan Clinical Oncology Group Study (JCOG1113, FUGA-BT)2016 · 54 citations