Observation shows RIPK1/RIPK3 amyloid fibrils infiltrate cells, suggesting a role in necroptosis. This implies structural mechanisms facilitating intercellular aggregation.
Key Points
RIPK1/RIPK3 amyloid fibrils can infiltrate recipient cells, inducing necroptosis.
Cryo electron microscopy revealed an S-shaped conformation of fibrils, promoting cellular infiltration.
Functional aggregates of RIPK1 and RIPK3 act as seeds for endogenous necrosome formation.
This study provides insights into the mechanism of RIPK1/RIPK3 interaction and cross-seeding.