Fast fMRI Signal Variations Reveal Widespread Changes in Frontotemporal Dementia

Motivation: Investigating glymphatic dysfunction in FTD using ultrafast fMRI may reveal unique biomarkers beyond structural atrophy, advancing our understanding of underlying mechanisms and potential early intervention targets. Goal(s): This study aims to determine if glymphatic dysfunction occurs in FTD by assessing CV changes across brain regions with ultrafast fMRI, beyond structural degeneration. Approach: Using ultrafast 10 Hz whole-brain fMRI (MREG), we measured the coefficient of variation across brain regions in FTD patients and age- and sex-matched healthy controls. Results: CV values were significantly elevated in FTD patients compared to controls, with the most prominent increases observed in gray matter regions across the brain. Impact: Findings suggest that ultrafast fMRI can detect glymphatic dysfunction in FTD, offering new insights into disease mechanisms. This approach may lead to novel diagnostic biomarkers and guide therapeutic strategies targeting glymphatic impairment, improving early detection and intervention for neurodegenerative diseases.