Quantitative analysis shows neurochemical asymmetries in epilepsy patients, suggesting improved diagnostic capabilities.
Motivation: Our motivation is to study neurochemical changes using Magnetic Resonance Spectroscopic Imaging (MRSI) in MR-negative patients with epilepsy whose structural MRI fails to reveal the Seizure Onset Zone (SOZ). Goal(s): Regionally analyzing the MRSI maps for different metabolites in the main lobes of the brain. Approach: Finding the median of Concentration Estimates (CE), we defined the highest relative difference between left and right hemisphere to highlight asymmetries which we compared with the clinically defined SOZs. Results: We found a relationship between neurochemical asymmetries and SOZ in 7 out of 10 patients. Impact: For the first time, we established regional concentration estimates of neurochemicals in epilepsy patients using 7T MRSI. Detecting abnormal concentrations could improve the diagnostic performance in MR-negative patients.
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Shayeste et al. (2025) studied this question.
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