Prospective Motion Correction of Arterial Spin Labelling Demonstrated with Patient-Informed Motion

Motivation: Arterial Spin Labelling is a promising non-invasive technique for cerebral perfusion measurement, but its sensitivity to patient motion limits its clinical application. This research explores prospective motion correction (PMC) to enhance ASL's reliability in motion-prone patient groups. Goal(s): To evaluate whether PMC using the Tracoline device improves the quality of Perfusion Weighted Imaging (PWI) in ASL scans affected by motion. Approach: ASL scans were conducted with PMC enabled, using head motion data from Tracoline to adjust the scan geometry in real-time during image acquisition. Results: PMC significantly reduced motion artefacts, improving PWI quality and similarity to ground truth scans without motion. Impact: This study demonstrates that prospective motion correction significantly enhances ASL image quality, making it more clinically viable for motion-prone patients. The findings encourage further exploration of real-time correction methods, potentially expanding ASL's diagnostic applicability across diverse patient groups.