The Application of New Models WMTI and MAPL in Assessing White Matter Microstructural Damage in Non-basal Ganglia Subcortical Ischemic Stroke

Motivation: Despite the prevalent use of DTI and DKI in assessing ischemic stroke, these methods fall short in accurately characterizing non-Gaussian diffusion behavior in brain tissues, often leading to an underestimation of microstructural changes. Goal(s): evaluate the feasibility of the models WMTI and MAPL for the quantitative detection of microstructural changes in brain tissue during ischemic stroke Approach: This study introduced the model WMTI and MAPL to enhance the assessment of white matter microstructural damage in non-basal ganglia subcortical ischemic stroke Results: The study proved that the diffusion models WMTI and MAPL are feasible for assessing ischemic stroke. Impact: Compared to traditional diffusion models DTI and DKI, the novel diffusion model MAPL exhibits higher sensitivity in describing changes in brain tissue microstructure. Additionally, changes observed during follow-up are positively correlated with NIHSS changes, making it a potential biomarker for estimating brain injury in ischemic stroke.