Motivation: This study addresses the need for precise, region-specific assessment of glucose uptake in the kidney, aiming to enhance understanding of renal physiology and pathology through improved DGE MRI. Goal(s): The goal of this research is to measure a full Z-spectrum at sufficient temporal resolution combined with model-based analysis techniques. Approach: We applied a modified Bloch-McConnell equation fitting approach, using MRI data from a wildtype mouse with controlled glucose infusions, to capture regional glucose dynamics in renal tissues. Results: The adapted model successfully quantified glucose uptake in distinct kidney regions, achieving consistent amplitude patterns over time and highlighting region-specific glucose distribution. Impact: This work provides a refined method based on Bloch-McConnell fitting for quantifying renal DGE MRI data, enabling clearer insights into renal function and pathology. It opens new pathways for studying regional kidney metabolism and renal diseases.
Lippe et al. (Tue,) studied this question.