Voxel-wise assessment reveals significant reduction in superior colliculus in female ferrets, indicating age susceptibility.
Motivation: An open-ended question in normal aging is how the brain changes over time and which regions are most susceptible to age-related changes. Goal(s): Using bias-free voxel-wise approach and evaluating warp fields using the logarithm of the determinant of the Jacobian (LogJ), we investigated age-related changes in the female ferret. Approach: We imaged four female ferrets at 1-2 years of age and later at 3-4 years of age using diffusion tensor imaging. Results: Average LogJ maps revealed 24.8% reduction in the superior colliculus. Impact: Voxel-wise morphology in the ferret allows us to track age-related changes in a longitudinal fashion.
No takes yet. Share an insight, caveat, or question.
Dieckhaus et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: