Observational analysis reveals changes in white matter PVS indices in adolescents with MDD, suggesting implications for glymphatic system function.
Motivation: Perivascular spaces (PVS) is the major component of glymphatic system (GS). However, the link between GS function in the alterations of white-matter microstructure among major depressive disorder (MDD) remains unclear. Goal(s): To investigate the changes of brain PVS in adolescents with depression by using MRI Approach: The PVS indexes of white matter were calculated by using T1WI and T2WI in adolescents with MDD. Results: Our preliminary results suggest that PVS volume and volume fraction have changed in the cerebral white matter and hippocampus in adolescent patients with MDD. Impact: These results will provide a new perspective for the study of the altered neuropathological mechanism of brain PVS in adolescents with depression
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Yin et al. (2025) studied this question.
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