Motivation: Preclinical 2D 1H-FID-MRSI has offered great and reproducible metabolite maps on the rat brain. The technique can be extended for whole-brain acquisition for richer information. Goal(s): Implement and test the feasibility of 3D and multislice 1H-FID-MRSI for rat brain metabolite mapping. Approach: Using optimized compressed sensing schemes to accelerate 3D and multislice acquisition, for volumetric acquisition in the rat brain. Results: Both methodologies have produced great through-plane coverage and concentration estimates are in line with 2D FID-MRSI measurements. Impact: 3D and multislice 1H-FID-MRSI can offer greater insight in the rat brain metabolism, enabling finer description of neurodegenerative diseases within preclinical models, such as the bile duct ligation rat model for hepatic encephalopathy.
Alves et al. (Tue,) studied this question.