Longitudinal analysis shows increased water permeability in HD mouse model, suggesting early disease biomarkers.
Motivation: Huntington's disease (HD) lacks disease-modifying treatments. Investigating blood-brain barrier (BBB) water permeability may reveal early biomarkers of disease progression. Goal(s): The study aims to assess BBB water permeability in the zQ175DN HD mouse model by analyzing longitudinal changes in water exchange time using multi-TE ASL MRI. Approach: Analysis was performed in control and HD mice at 3, 6, and 9 months of age, focusing on water exchange time in striatum and cortical regions. Results: Reduced water exchange time was observed in the somatosensory and cingulate cortex in HD mice, suggesting increased BBB permeability at 9 months of age. Impact: This study indicates that using the non-invasive multi-TE ASL MRI technique, alterations in water exchange time can be detected in the zQ175DN mouse model of Huntington's Disease at 9 months of age.
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Rijswijk et al. (2025) studied this question.
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