Impacts of Pulmonary Regurgitation on Correlations Between Radiomic Features and Left Ventricular Strains in rTOF Patients

Motivation: Pulmonary regurgitation (PR) is crucial in repaired Tetralogy of Fallot (rTOF) patients. Radiomics analysis of cine images can detect structural and functional changes in the heart. Goal(s): To assess the relationship between radiomics features, CMR indices, and myocardial strains in rTOF with different PR severity. Approach: Radiomics features of cine images were extracted to classify rTOF with PR<40% and ≥40%. Pearson's correlation was employed to evaluate correlations between radiomics features and strains. A multivariable regression was used to predict strains by CMR indices and radiomics features. Results: rTOF with mild PR showed significant correlations between radiomics features and strains. Impact: Different PR severity had differential impacts on the correlations between radiomics features and strains. The integrating radiomics features and CMR indices could improve the assessment of PR severity and LV strain function in rTOF patients.