Multimodal MRI Reveals Neurobiological Alterations in High Schizotypy: Insights from Diffusion and Perfusion Imaging

Motivation: The etiology of schizophrenia still remains unclear that makes it harder to predict its progression. Goal(s): This study aims to highlight early neurobiological markers associated with schizophrenia. Approach: This study employed diffusion and perfusion weighted imaging to identify the structural and functional brain changes in high schizotypy population, individuals with subclinical manifestations of schizophrenia. Results: Diffusion weighted imaging reveals significant white matter abnormalities specifically in right hemisphere. Perfusion imaging shows prolonged arterial transit time and reduced cerebral blood flow in few brain regions. Impact: Our findings suggest early potential biomarkers of schizophrenia through multi-modal MRI, which is critical for early diagnosis and intervention strategies in high-risk populations.