Prospective analysis demonstrates time-dependent diffusion imaging's ability to predict 1p/19q codeletion status, suggesting its clinical value.
Motivation: The diagnostic performance of time-dependent diffusion-weighted imaging in predicting the 1p/19q codeletion status in IDH-mutant gliomas remains unclear. Goal(s): To investigate the clinical value of time-dependent diffusion MRI-based microstructural mapping for noninvasive prediction of 1p/19q codeletion status in IDH-mutant gliomas. Approach: A prospective collection of patients with IDH-mutant brain gliomas was conducted to evaluate the microstructural differences between the 1p/19q codeleted and non-codeleted groups. The diagnostic performance of each feature was assessed using ROC analysis. Results: Microstructural parameters, including D, Vin and Cellularity, are efficient in predicting 1p/19q codeletion status in IDH-mutant gliomas. Impact: Time-dependent diffusion-weighted imaging provides a non-invasive approach to characterize microstructural features, including cell size and density. It shows promise in predicting the 1p/19q codeletion status in IDH-mutant gliomas, potentially aiding clinicians in selecting optimal treatment strategies and conducting prognostic analyses.
No takes yet. Share an insight, caveat, or question.
Zhang et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: