Observational analysis of myocardial microstructure using DTI phenomapping, suggesting accuracy of the technique.
Motivation: We sought to validate our approach of acquiring and characterizing myocardial microstructure through voxel-scale phenomapping of the human heart in vivo. Goal(s): Our goal was to validate our approach using a high-quality ex vivo data set. Approach: We used the voxels from diffusion tensor MRI scans of human hearts ex vivo and characterized the resulting phenomapping matrices. Results: The in vivo and ex vivo hearts showed comparable helix angle derived metrics and presented similar trends for principal component analysis and k-means clustering. Impact: DTI phenomapping of the human in vivo and ex vivo yielded near identical results, validating the accuracy of the technique to characterize myocardial microstructure.
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Rock et al. (2025) studied this question.
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