Effects of Gamma Knife Radiosurgery on Optic Pathways in Sellar Tumor Patients: Voxel-based and Tract-based DTI Analysis

Motivation: Gamma Knife radiosurgery (GKRS) for sellar tumors risks radiation exposure to critical optic pathways. This study investigates the possible GKRS-induced microstructural changes and thereby assessing treatment toxicity. Goal(s): Gamma Knife radiosurgery (GKRS) for sellar tumors risks radiation exposure to critical optic pathways. This study investigates the possible GKRS-induced microstructural changes and thereby assessing treatment toxicity. Approach: Gamma Knife radiosurgery (GKRS) for sellar tumors risks radiation exposure to critical optic pathways. This study investigates the possible GKRS-induced microstructural changes and thereby assessing treatment toxicity. Results: TBSS and VBA analyses showed no significant microstructural changes in multiple DTI parameters within the optic radiation. Impact: Advanced DTI analysis with TBSS and VBA confirms that GKRS preserves optic radiation integrity in sellar tumor patients. Future studies can extend these methods to assessing long-term radiation effects on neural pathways and refining neuroprotective strategies in radiotherapy.