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Exploratory analysis reveals reduced hippocampal volume in patients with cognitive impairment due to post-covid-19 condition, indicating neural changes linked to this condition.
Motivation: Assessing brain alterations in post-COVID-19 condition (PCC) can enhance our understanding of the underlying mechanisms driving neurocognitive impairment in this condition. Hippocampal alterations are often related to cognitive impairment, and previous studies have linked these alterations to PCC. Goal(s): To conduct an exploratory analysis of potential hippocampal volumetric alterations in patients experiencing cognitive impairment due to PCC. Approach: Comparison of brain volumetric data from Freesurfer Hippocampal Subfield segmentation of patients with PCC to that of healthy controls (HC). Results: Patients with PCC show reduced bilateral hippocampal volume in most regions of the hippocampal body compared to the HC group. Impact: Understanding the biological changes associated with PCC advances the identification of underlying mechanisms and could guide the development of effective treatments for this condition.
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Dell’Orco et al. (2025) studied this question.
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