Structural MRI Analysis of Pregnancy-Related Brain Region Volumetric Changes in Mice: A Step Toward a Translational Animal Model

Motivation: Human MRI studies show pregnancy-induced brain changes, yet mechanisms and implications remain unclear. A preclinical animal model may clarify pregnancy's effects on brain structure, offering insights for translational research. Goal(s): To establish a mouse model capturing structural brain changes linked to motherhood, enabling comparisons with human studies. Approach: We conducted longitudinal MRI scans on primiparous and nulliparous mice, creating a study-specific brain template to analyze volumetric changes in brain regions. Results: Contrary to human data, we found significant gray matter volume increases in primiparous mice, suggesting potential hormone-driven brain growth and highlighting this model's value for further translational research. Impact: This study an attempt to establish a foundational mouse model to explore pregnancy-related brain reorganization based on volumetric changes across brain regions. Further exploration could advance understanding of maternal brain plasticity and inform research on cognitive and emotional health postpartum.