What type of study is this?

This is a Quantitative Study study.

September 17, 2025

Amide Proton Transfer-weighted MRI and DWI as Biomarkers for Predicting Tumor Grades in Head and Neck Squamous Cell Carcinoma

Key Points

Both APTw MRI and ADC are effective in predicting tumor grades, improving accuracy when combined for clinical assessment.
Tumor grade determination via APTw MRI and DWI provides unique insights into the tumor microenvironment compared to invasive biopsy.
The use of non-invasive imaging techniques in HNSCC tumor grading may enhance patient management and preoperative assessment.
Pathological confirmation of tumor grades strengthens the validity of findings from APTw MRI and DWI evaluations.

Abstract

Motivation: Amide proton transfer-weighted (APTw) MRI and DWI are advanced functional MR technologies that provide microstructural information about tissues. The histopathological grade of HNSCC is typically determined through invasive biopsy. Accurate and non-invasive methods are needed. Goal(s): To investigate the potential of APTw MRI and DWI for predicting the histopathological grade of HNSCC. Approach: Tumor grade was confirmed through pathological confirmation. APTw and ADC values were evaluated and compared across tumors with different grades. Results: Both APTw and ADC were found to be effective in predicting the histopathological grades. The diagnostic accuracy was enhanced when both parameters were combined. Impact: APTw and ADC provide unique insights into tumor microenvironment. Incorporating these imaging modalities into clinical practice offers a non-invasive approach for tumor grading, which could enhance preoperative assessment and potentially improve patient management.

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