Cross-sectional analysis reveals correlations between nonalcoholic fatty liver disease and fat distribution metrics, suggesting improved diagnostics.
Motivation: Nonalcoholic fatty liver disease (NAFLD) is an escalating health issue, urgently requiring a comprehensive analysis of abnormal fat deposition and distribution in the body. Goal(s): To explore the correlation between NAFLD and whole-body fat distribution, visceral fat infiltration, and musculoskeletal fat deposition. Approach: Utilize high-precision whole-body fat quantification to analyze fat distribution and proton density fat fraction (PDFF) in various tissues, with a focus on clinical applicability for NAFLD. Results: High-precision whole-body fat quantification demonstrated good correlations in NAFLD, proving its capability to identify systemic lipid metabolic disorders in clinical diagnostics. Impact: High-precision whole-body fat quantification offers a non-invasive, accurate method for assessing fat distribution, potentially revolutionizing NAFLD diagnosis and classification, setting new clinical standards, and guiding future advancements in lipid metabolic disease diagnostics.
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Liu et al. (2025) studied this question.
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