Vascular and metabolic responses to elevated circulating PDGF-BB in mice: A multiparametric MRI study

Motivation: Elevated circulating PDGF-BB has been implicated in various aging-related processes. However, there is a lack of neurofunctional proof to support the underlying relationship. Goal(s): Here, we aim to investigate the vascular and metabolic responses to elevated circulating PDGF-BB in mice. Approach: Non-contrast-agent multiparametric MRI methods were applied to examine the potential alterations in cerebral blood flow (CBF), oxygen extraction fraction (OEF), cerebral metabolic rate of oxygen (CMRO2), and brain microstructures. Results: We found that elevated circulating PDGF-BB was associated with impaired blood supply and elevated brain metabolism, suggesting that excessive circulating PGDF-BB is a pro-aging factor. Impact: Excessive circulating PDGF-BB is associated with impaired blood supply and hypermetabolism in mice, which aligns with the major pathophysiological changes in human aging. It provides a functional proof that excessive PDGF-BB is a pro-aging factor and a potential therapeutic target.