Findings demonstrate that AIMP CpG methylation is linked to bevacizumab response in glioblastoma, suggesting potential biomarkers.
Bevacizumab treatment response is associated with specific AIMP CpG site methylation status in gliomas. A, Significant association between two CpG sites and astrocytoma (n = 22) pathologic response to bevacizumab treatment. A Student t test P value < 0.05 was considered significant. B, Forest plots depicting Cox proportional hazards model univariate (i) and multivariate (ii) analysis for the effects of AIMP1/2/3 CpG methylation status in GBM (n = 27) and astrocytoma (n = 24).
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Noor et al. (2025) studied this question.
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