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September 17, 2025Frontiers in Cellular and Infection MicrobiologyOpen Access

Pingwei Powder alleviates high-fat diet-induced colonic inflammation by modulating microbial metabolites SCFAs

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Authors

TLTangjuan LiuGOGuosen OuJWJialin Wu

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Overview

Network pharmacology and gut microbiota analysis reveal how Pingwei Powder influences SCFAs levels in colonic inflammation.

Key Points

  • PWP enhances SCFA-producing gut bacteria and promotes gut health, reducing colonic inflammation.
  • Experimental validation showed PWP significantly downregulated key proteins in the PI3K/AKT/mTOR pathway.
  • 16S rDNA sequencing indicated PWP's efficacy is linked to increased abundance of specific gut microbiota.
  • This research highlights the interplay between gut microbiota and pharmacological effects in treating ulcerative colitis.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68d45e5831b076d99fa5ea92https://doi.org/10.3389/fcimb.2025.1628488
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