This review highlights the IgE-mediated Cannabis allergy in plant food allergy, suggesting a need for better diagnostic tools.
IgE-mediated Cannabis allergy (CA) is a potentially severe immediate hypersensitivity reaction caused by exposure to cannabis derivatives, which is frequently associated with a secondary form of plant food allergy. Since the first description of CA in the 1970s, the research on CA and understanding of its allergenic profile has grown. To date, five Cannabis sativa allergens have been officially registered and many others have been identified as putative. This review provides a comprehensive overview of molecular insights in the field as of 2025. Many questions concerning CA remain unanswered, and the exact clinical role of certain allergens is unclear to date. Given the increasing worldwide use of cannabis, further research is needed to fill current knowledge gaps and provide accessible and effective diagnostic tools.
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Toscano et al. (2025) studied this question.
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