Immunohistochemistry reveals angiogenesis linked to nestin and CD15 expression in germinoma vasculature.
Germinomas constitute two-thirds of intracranial germ cell neoplasms, with a woman: male ratio of 8:22. A characteristic of this tumor is its adequate vascularity, which has not been previously studied with markers such as Nestin, YAP and CD15, and which can provide valuable information about the biology of this tumor. These markers were analyzed by immunohistochemistry, showing tumor blood vessels cytoplasmic staining for nestin and for CD15, demonstrating angiogenesis as an important mechanism in germinomas.
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Alcalá‐Romero et al. (2025) studied this question.
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