Normal-tension glaucoma (NTG) is a complex form of primary open-angle glaucoma characterized by progressive optic nerve damage despite normal intraocular pressure (IOP) levels.This review summarizes current concepts regarding the key role of biomechanical factors in the pathogenesis and diagnosis of NTG. Particular emphasis is placed on the structural and functional properties of the corneoscleral shell, including the cornea and sclera, as well as the lamina cribrosa (LC), which determine tissue resistance to mechanical stress. Modern methods for assessing biomechanical properties — such as corneal hysteresis, dynamic tonometry (ORA, Corvis ST), and lamina cribrosa imaging using optical coherence tomography — are of special importance, as they allow the detection of early changes that may not be identified with conventional diagnostic tools.The review emphasizes the need for further research to standardize biomechanical parameters and develop novel diagnostic approaches, including stress tests. Integrating biomechanical data into clinical practice may improve the early detection of NTG.
Arutyunyan et al. (Sat,) studied this question.
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