Three new sesquiterpenoid dimers exhibit unique structures and lipid-lowering properties, highlighting potential therapeutic implications.
Three architecturally novel cadinane sesquiterpenoid dimers, distahlianins A-C (1-3), were isolated from Stahlianthus involucratus. Compounds 1 and 2 are characterized by an unusual 5,6-spirocyclic scaffold annulated with oxygenated heterocycles to form intricate 6/6/5/6/6/6 and 6/6/5/5/6/6 hexacyclic frameworks, respectively. Compound 3 features a unique dimeric skeleton formed by two monomeric units bridged through a cyclopentane ring. Intriguingly, structural analysis revealed a unique C14 methyl migration (C-9→C-8) in the left monomer unit of 3, representing a new cadinane skeletal feature. Compound 3 exhibited potent lipid-lowering activity, with mechanistic evidence pointing to lipogenesis suppression.
No takes yet. Share an insight, caveat, or question.
Ji et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: