Influence of Low-Level Laser Therapy on the major salivary glands in individuals with Sjögren’s Syndrome and impact of oral health on quality of life: A pilot study

Abstract PurposeThis randomized controlled clinical trial pilot study aimed to evaluate the effectiveness of Low-Level Laser Therapy (LLLT) applied to the major salivary glands in individuals with Sjögren’s Syndrome (SS) and the impact of oral health on quality of life (QoL).MethodsPatients presenting with hyposalivation or low salivary flow due to SS were recruited, randomized, and allocated into two groups: laser group (LG) and laser plus saliva substitute group (LG/SS). LLLT was systematically applied to the participants’ major salivary glands in 16 sessions over a two-month period. Salivary flow measurements and assessments using the Oral Health Impact Profile (OHIP-14) were performed at baseline (first appointment) and at 1, 2, 3, and 5 months following the initiation of LLLT.ResultsThere was a significant increase in both stimulated and unstimulated salivary flow in the groups. This improvement in salivary production was accompanied by a reduction in the negative impact of oral health on QoL, as measured by OHIP-14 scores.Conclusion LLLT proved effective in increasing salivary flow and contributed to improving oral health-related QoL in individuals with SS.