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September 18, 2025Experimental GerontologyOpen Access

Relationship between stress systems and inflammation in older adults concerned about falling – Findings from the FEARFALL study

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Authors

AMAnja MüllerRKRobert KobCSCornel Sieber

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Overview

Randomized-controlled trial reveals links between stress system activity and inflammation in older adults, suggesting perceived control impacts health outcomes.

Key Points

  • Higher perceived control over falling significantly relates to cortisol dynamics in older adults.
  • C-reactive protein and interleukin-6 showed associations with BMI and age, but not with concerns about falling.
  • Increased cortisol levels correspond with better stress system regulation among older adults concerned about falling.
  • Findings suggest psychological factors may impact physiological stress responses in older populations.

Cite This Study

Müller et al. (2025) studied this question.

synapsesocial.com/papers/68d462d231b076d99fa6245ahttps://doi.org/10.1016/j.exger.2025.112899
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Targeting concerns about falling to modulate biological stress systems: Effects of a multicomponent randomized controlled trial in older adults2025 · 1 citations
  2. 2Balancing on the edge of age: neuroendocrine, mental health and functional fitness correlates of fear of falling in older women2025 · 1 citations
  3. 3Negative perceptions of ageing are associated with fall-related concerns in community-dwelling older adults2026
  4. 4Perceived control over falling: a qualitative study of psychological aspects in older adults with fall concerns2026
  5. 5Correlation between Activity Restriction and Fear of Falling in Community Dwelling Indian Older Adults: A Cross-sectional Study2025