The Effect of Different Concentrations of Onosma Tinctoria Plant on Blood Lipids and Atherosclerosis Index in Laboratory Rats.

Background: Herbal products, botanical products, or phytomedicines are all terms that refer to plant-based products that are utilized for the management of diseases or preserve health. Heart disease is a generic word that refers to a variety of chronic & acute medical problems that affect one or more components of the heart. Aims of study: This research aimed to determine the effect of various concentrations of Onosma tinctoria plant on blood lipids and atherosclerosis index in laboratory mice. Materials and Methods: Twenty-Four Sprague-Dawley albino mice, aged ten weeks, with a weight of 150 ±10, were split into four groups: the 1st was a control negative nourished on a basal diet alone, while the other three groups nourished on basal diet plus different levels of Onosma tinctoria plant (5%,10%, 15%) for 28 days. The experiment concluded with a blood sample & biochemical examination. Results: F.S.VLDL-c, and Atherogenic index recorded the greatest value for 5 % Onosma group, whereas the lowest value in the 15%Onosma group after 4 weeks. But F.S.LDL-c , F.S. Cholesterol , S.GPT and S.GOT recorded the highest value in 5% group, but the lowest value was recorded 15% Onosma group after 4 weeks. Conclusion: Onosma tinctoria may enhance vascular health and diminish the risk of cardiovascular disease by improving the lipid profile & elevating blood concentrations of antioxidants. DOI : https://doi.org/10.52783/pst.2361