Age-Related Changes in the Vascular Plexus of the Rat Brain Are Accompanied by the Accumulation of Lipofuscin in the Cells of the Integumentary Epitheliumauthors

BACKGROUND: The choroid plexus of the brain is the main component of the blood-cerebrospinal fluid barrier, consists of stromal and integumentary epithelium, the cells of which belong to a population of slowly renewing tissues and can accumulate lipofuscin with age, similar to other brain cells. AIM: The purpose of this study was to test the hypothesis that the epithelium of the choroid plexus of the rat brain is characterized by the accumulation of lipofuscin during aging. METHODS: The study was performed on male Wistar rats of different ages: 4-5 months (n=3), 18 months (n=3), 28 months (n=3). The presence of lipofuscin in the tissues was assessed by confocal microscopy using its autofluorescence property. RESULTS: In the course of the study, it was shown that with aging, lipofuscin accumulates in the epithelium of the choroid plexus of the brain in rats. CONCLUSION: Further study of the conditions and experimental effects under which the accumulation of lipofuscin may be delayed will allow us to develop a methodology for testing new medical technologies and drugs that slow down the aging of brain structures.