Diagnostic errors in older patients: a secondary analysis of case reports

Objectives Diagnostic errors are a significant source of patient harm and occur more frequently in older adults due to comorbidities, symptom ambiguity, and communication barriers. However, how these errors differ between older and younger patients remains unclear. The aim of this study was to examine the characteristics of diagnostic errors in older patients using published case reports. Methods We performed a secondary analysis of 534 case reports from a systematic review. Cases were divided into older (≥65 years, n=115) and younger (<65 years, n=419) groups. Data were extracted and coded using the diagnostic error evaluation and research (DEER), reliable diagnosis challenges (RDC), and generic diagnostic pitfalls (GDP) frameworks. Results Older patients had significantly more DEER codes per case than younger patients (2.5 vs. 2.0; p=0.01). Key DEER codes were more frequent in older adults, including “Physical examination: Failure in weighing” (7.8 vs. 2.9 %), “Assessment: Failure/delay in considering the diagnosis” (74.8 vs. 64.0 %), and “Assessment: Failure/delay to recognise/weigh urgency” (7.8 vs. 2.9 %). In RDC, “Diagnosis of complications” was also more common in older patients (11.3 vs. 5.3 %). No significant differences were found in GDP coding. Conclusions Diagnostic errors involving failure to consider the correct diagnosis, recognize urgency, and identify complications were more common in older patients. Understanding these mechanisms is essential to develop diagnostic strategies specific to older patients.