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September 19, 2025

The Mediating Role of Structural Connectivity in Genetic Effects on Functional Brain Networks

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Authors

SGSimiao GaoSDShengxian DingXZXinzhi Zhang

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Overview

Causal mediation analysis reveals structural connectivity's role in linking SNPs and functional connectivity in neurodevelopment.

Key Points

  • Genetic variations significantly influence functional connectivity in the brain, indicating complex interactions.
  • Key findings from mediation analyses show that structural connectivity mediates genetic effects on functional brain networks.
  • Genome-wide association studies identified numerous SNPs related to brain structural and functional traits across a large sample.
  • This research enhances understanding of genetic pathways affecting brain architecture and function during development.

Cite This Study

Gao et al. (2025) studied this question.

synapsesocial.com/papers/68d464f131b076d99fa642d5https://doi.org/10.1101/2025.09.16.25335920
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