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September 19, 2025Cancer Epidemiology Biomarkers & Prevention

Abstract B135: Deletion of HDAC1 demonstrates alternative metabolic response in pancreatic cancer

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Authors

DCDon-Gerard CondeEZEsther H. ZhouMFMaximilian Farma

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Overview

Analysis reveals HDAC1 absence alters metabolic pathways in pancreatic cancer, suggesting new therapeutic targets.

Key Points

  • Deletion of HDAC1 leads to distinct growth phenotypes in pancreatic cancer cell lines, indicating important metabolic shifts.
  • Differential expression of metabolic targets was noted in cell lines lacking HDAC1, showing its regulatory role in metabolism.
  • Using CRISPR/Cas-9, pancreatic cancer models demonstrated a shift to oxidative phosphorylation after HDAC1 knockout.
  • Understanding these metabolic changes may improve targeting strategies for specific pancreatic cancer patient subgroups.

Cite This Study

Conde et al. (2025) studied this question.

synapsesocial.com/papers/68d464f831b076d99fa646afhttps://doi.org/10.1158/1538-7755.disp25-b135
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